Born with only half a brain, Mack can speak normally, graduated from high school and has an uncanny knack for dates. At 27, doctors determined that the right side of her brain had essentially rewired itself to make up for function that was likely lost during a pre-birth stroke. But her childhood and young adult years were fraught with frustration.

“We were surprised to see the extent of the lesion in her brain, which basically took away the left side of her brain,” said Grafman. “There’s some very deep structures remaining, but the surface of her brain, the cortex is 95 percent gone and some of the deeper structures, structures that control movement, are missing. These are all structures that are important for movement, behavior, cognition.”

The only answer, Grafman said, was that Mack’s brain has rewired itself. The remaining half took over some of the essential functions that are normally done by the left, such as speaking and reading. That rewiring, however, came at a cost.